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5HTP Supreme is a synergistic formula of 5-hydroxytryptophan (100 mg) and vitamin B6 (20 mg) for supporting overall neurotransmitter metabolism by providing precursors of serotonin. 5-HTP readily enters the blood brain barrier, however conversion into serotonin requires the cofac­tor vitamin B6, which is included in this formula. 5HTP Supreme may be used during the day to support healthy mood or appetite or at bedtime to support sleep.


  • Helps to promote healthy mood balance
  • Helps to relieve fibromyalgia symptoms
  • Helps to reduce the severity and duration of migraine headaches when taken as a prophylactic
  • Non GMO, gluten free, vegetarian

Medical Ingredients 

Amount per capsule:

  • L-5-Hydroxytryptophan (5-HTP, Griffonia simplicifolia-Seed) – 100 mg
  • Vitamin B6 (Pyridoxal 5-phosphate) – 20 mg

Non-medicinal Ingredients

Microcrystalline cellulose, l-leucine.

Made with non-GMO ingredients.

Suggested Use 

Adults: Take 1 capsule three times per day, or as directed by your health care practitioner. To minimize the risk of gastrointestinal side effects, start dosing at 50-100mg, 2-3 times per day and slowly increase to effective dose over 2 week period. Take with food. For symptoms of fibromyalgia, use for a minimum of 2 weeks to see beneficial effects. Consult a health care practitioner for use beyond one year.


Consult a health care practitioner prior to use if you are pregnant or breastfeeding, if symptoms persist or worsen, or if you are taking carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John’s wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Discontinue use if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain. Do not use if you have scleroderma. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or activities requiring mental alertness. Some people may experience diarrhea, nausea, vomiting and abdominal pain accompanied by severe muscle pain or skin changes.