- May reduce severe and frequent menopausal symptoms (such as hot flashes and/or night sweats)
- PROMOTES BONE MINERAL DENSITY - The main active compound of Osteoben is the isoflavone genistein, a non-soy phytoestrogen which works to support already healthy bone mineral density.
- ADVANCED SYNERGISTIC FORMULA - In addition to genistein aglycone, calcium and vitamin D, this formula also provides other important bone-building nutrients such as magnesium malate and chelated zinc. When combined with a healthy diet, and regular exercise, may reduce the risk of developing osteoporosis.
- K2 AS MK-7 - Vitamin K2 helps prevent calcium deposition in arteries and soft tissue and helps 'guide' calcium into bone. It is metabolized slowly throughout the day.
- Does not contain Boron.
About Genistein
Many epidemiological studies have been conducted demonstrating that high isoflavone intake has bone-sparing effects. Research suggests that genistein exerts its effect by managing the metabolic imbalance in bone tissue induced by ovarian hormone depletion, an important fact since the primary type of osteoporosis affects postmenopausal women.
Genistein is a phytoestrogen that acts as a mild SERM (selective estrogen receptor modulator) which may positively regulate bone cell metabolism without serious side effects.
The genistein aglycone in Osteoben™ is from a non-soy plant source.
Medicinal Ingredients (per capsule)
- Genistein: 13.5 mg
- Calcium (Dicalcium malate): 100 mg
- Magnesium (Dimagnesium malate): 100 mg
- Vitamin D3 (Cholecalciferol): 6.25 mcg (250 IU)
- Vitamin K2 (Menaquinone 7): 12.5 mcg
- Zinc (Zinc bisglycinate): 2 mg
Non-Medicinal Ingredients
Microcrystalline cellulose, magnesium stearate.
Recommended Dose
Post-menopausal women: 2 capsules 2 times per day with food, or as directed by a physician. Take a few hours before or after taking other medications. Consult a health care practitioner for use beyond one year.
Caution
Ensure you are up-to-date on mammograms and gynecological evaluations prior to use.
Consult a health care practitioner prior to use if you are taking blood thinners, if you have a history of hormonal or gynecological disease, including ovarian cancer, endometriosis, and/or uterine fibroids, if you have a liver disorder or develop liver-related symptoms (e.g. abdominal pain, jaundice, dark urine), if you are taking hormone replacement therapy (HRT), including thyroid hormone replacement therapy. Discontinue use and consult a health care practitioner if you experience breast pain, discomfort and/or tenderness, or if you experience a recurrence of menstruation and/or uterine spotting. Do not use if you currently have or previously had breast cancer and/or breast tumors or if you have a predisposition to breast cancer, as indicated by an abnormal mammogram and/or biopsy, or a family member with breast cancer. Some people may experience diarrhea.
NON RETURNABLE ITEM.
Frequently Asked Questions
Q: What is the botanical source of genistein?
A:The botanical source is Sophora japonica. There is no soy in Osteoben.
Q: Why the di-Magnesium Malate form of magnesium?
A: Di-magnesium malate is an exceptionally well-absorbed form of magnesium with high enough levels of elemental magnesium to allow an appropriate daily dose of Osteoben in 4 capsules daily.
Q: Is this product appropriate for male patients?
A: Yes. Genistein is protective of prostate health in men in a manner similar to the way it protects breast health in women. Most men who are concerned about osteoporosis or osteopenia are over 50 years of age and may also be concerned about prostate health. Osteoben therefore may provide a dual benefit in those patients.
Genistein is a common component of a plant-based diet consumed by healthy men and women. Research has shown that genistein does not lower testosterone. A 2010 meta-analysis (Fertil Steril. 2010 Aug;94(3):997-1007) showed no effect of isoflavones on testosterone or other reproductive hormones in men. Phytoestrogens have extremely mild estrogenic effects, in the range of 1,000 to 10,000 times less potent than estradiol. There is no data showing excess estrogenic effect of genistein in men when taken at dosages similar to that found in Osteoben.
Q: Is there a contraindication with coumadin?
A: No. Vitamin K1 in contraindicated in patients on Coumadin, but not Vitamin K2. Osteoben contains Vitamin K2, but not K1.
Q: Is it necessary or unnecessary for a patient to take TRF with Osteoben™?
A: It is not necessary. Research has demonstrated increased bone density using just the ingredients in Osteoben. However patients may experience additional benefit from taking TRF with Osteoben since it provides additional support that acts in a complementary way.
Q: Is Osteoben™ better for osteolytic or oteoblastic bone degradation?
A: Osteoben reduces osteoclastic activity and improves osteoblastic function, thus promoting a net gain in Bone Mineral Density. It has not been studied in bone diseases that are specifically either osteolytic or osteoblastic in nature.
Q: Should women take additional calcium with Osteoben™?
A: Patients consuming a typical diet along with Osteoben would have a calcium intake that approximates the recommended 1,200 mg per day for women over 50 years of age. Supplementing with excess calcium inhibits the absorption of magnesium and other minerals that are essential to bone health. Therefore, for most women additional calcium is not necessary and may have negative consequences.
Q: What is the advantage of having genistein in the formula?
A: Genistein combined with calcium and vitamin D is far more effective for managing bone loss than calcium and vitamin D alone. Research has shown that genistein (with calcium and vitamin D) increases bone density in menopausal women, while subjects on calcium and vitamin D alone continue to lose bone. In addition, genistein provides a number of other benefits including:
- Reduced frequency and severity of hot flashes in postmenopausal women
- Significant reduction in specific predictors of cardiovascular disease
- Reduces elevated fasting glucose and fasting insulin
- Improves insulin resistance
- Reduces elevated hs-CRP
- Reduces elevated homocysteine
- Reduces elevated total cholesterol and triglycerides
- Increases HDL cholesterol
- Positively affects leptin and adiponectin, hormones produced in adipose tissue that are involved in regulating appetite, fat metabolism and storage. Shorter term supplementation with isoflavones have been shown to reduce body weight in women
- Supports good prostate health in men
- Has no effect on testosterone or other reproductive hormones in men